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The use of Advair Diskus(R) 250/50 (fluticasone propionate and
salmeterol inhalation powder) demonstrated a 30% reduction in exacerbations
in patients with chronic obstructive pulmonary disease (COPD) who have a
history of exacerbations as compared with salmeterol alone, according to
new data presented today at the International Conference of the American
Thoracic Society meeting in Toronto.
COPD is a progressive, life-threatening lung disease that includes
chronic bronchitis, emphysema or both. Exacerbations are flare-ups or
episodes of worsening COPD symptoms that often require additional
treatment, such as antibiotics, oral corticosteroids and in some cases
hospitalization. Symptoms may include shortness of breath, or coughing up
excess mucus beyond normal day-to-day variations. Seventy-seven (77)
percent of patients with COPD report experiencing at least one exacerbation
within the past year.
The randomized study of 797 patients was a replicate study which found
that after a year of treatment, patients treated with Advair Diskus 250/50
had a 30% reduction in the rate of annual exacerbations compared to
salmeterol (p
About Advair in COPD
Advair Diskus 250/50 is indicated for the maintenance treatment of
airflow obstruction in patients with COPD, including chronic bronchitis
and/or emphysema. Advair Diskus 250/50 is also indicated to reduce
exacerbations in patients with a history of exacerbations. Advair Diskus
250/50 is the only approved strength for COPD because an efficacy advantage
of the higher strength Advair Diskus 500/50 over Advair Diskus 250/50 has
not been demonstrated.
Patients should only take one inhalation of Advair twice a day. People
with COPD taking Advair may have a higher chance of pneumonia. Patients
should call their doctor if they notice any of the following symptoms:
change in amount or color of sputum, fever, chills, increased cough, or
increased breathing problems. Advair may increase the risk of osteoporosis
and some eye problems (cataracts or glaucoma). Patients should have regular
eye exams. Thrush in the mouth and throat may occur. Patients should tell
their doctor if they have a heart condition or high blood pressure before
taking Advair. Do not use Advair with long-acting beta2-agonists for any
reason. Advair does not replace fast-acting inhalers for sudden symptoms.
For more information about Advair please visit gsk.
About GlaxoSmithKline (NYSE: GSK)
GlaxoSmithKline is one of the world's leading research-based
pharmaceutical and healthcare companies. GlaxoSmithKline is committed to
improving the quality of human life by enabling people to do more, feel
better and live longer. For company information visit gsk.
GlaxoSmithKline
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